Job Description

Biologists
Job Number: 21-15608
 
Be part of a company that delivers life-changing healthcare solutions. Eclaro is looking for a Biologists for our client in San Diego, CA. 
 
Eclaro’s client is a leader in the Biopharmaceutical Industry, providing quality, innovative, and affordable medicines that make a difference in the lives of patients all over the world. If you’re up to the challenge, then take a chance at this rewarding opportunity!
 
Position Overview:
  • The Molecular and Cellular Pharmacology Group in Oncology TRC focuses on delivering Client cancer therapeutics by engaging E3 ubiquitin ligases for targeted protein degradation.
  • We are seeking a motivated Associate Scientist with experience in drug discovery and in vitro pharmacology to participate in research focused on protein homeostasis for cancer therapeutics.
  • The successful candidate will work collaboratively in a multi-disciplinary environment to use cell-based assays in support of discovery of small molecules as development candidates (DCs) for clinical, design and execute in vitro studies to further our understanding of the mechanisms of Client compounds.
  • The Oncology TRC in Client is one of the fundamental research and early development engines delivering therapeutics to patients.
  • The group integrates discovery research through translational and early clinical development and focuses on numerous aspects of protein homeostasis including the ubiquitin-proteasome system, protein translation, and RNA processing and stability.
  • This thematic focus allows the group to capitalize on the cutting edge science that underpins the action of the companys most advanced drugs.
  • Not being bound by disease area or therapeutic modality creates a very dynamic, exciting and creative environment that exploits excellent science in biology, biochemistry, structural biology, computational biology and translational development.
 
Responsibilities:
  • Design and conduct in vitro experiments in cell biology (Transfection, Immunofluorescence, lenti-virus production), biochemistry (Western blot), molecular biology (DNA cloning), and assay development (ELISA, bDNA) with minimum supervision.
  • Engineer cells by editing genes by CRISPR-KO and -KI or by modulating gene expression by shRNA and characterize the cell models.
  • Maintain cell cultures and characterize cancer cell lines.
  • Hands on experience on RNASeq (more specifically READS+, 3P-seq) and eCLIP assay are plus.
  • Develop and implement relevant cell based assays to support identification, optimization, and characterization of Client chemical matter
  • Analyze and present data in an organized and timely manner
  • Work within and support biology needs for drug discovery teams
 
Qualifications:
  • Bachelors degree in a scientific discipline with at least 6 years of work experience or Masters degree with at least 4 years of industrial experience in a drug discovery setting.'
  • Understand cancer biology, biochemistry and molecular and cell biology as well as RNA regulation.
  • Keen on new technologies and familiarity with various cellular assays in high-throughput formats and automation equipment.
  • Strong data handling skills including importing/exporting data into/from database, organizing data for easy interpretation and experience with a variety of scientific/data analysis software applications.
  • Excellent communication, presentation, collaboration and organizational skills as well as ability to write protocols and technical reports with precision.
  • Multitasking, capability to pay attention to details, stay focused on key objectives, and deliver high quality data in a timely and well organized manner is essential.
  • Ability to work in a fast-paced dynamic team environment, flexibility to adapt to changes with a positive attitude.
  • PhD is a plus but not required
 
If hired, you will enjoy the following Eclaro Benefits:
  • 401k Retirement Savings Plan administered by Merrill Lynch
  • Commuter Check Pretax Commuter Benefits
  • Eligibility to purchase Medical, Dental & Vision Insurance through Eclaro
 
If interested, you may contact:
Chris Imbien
Chris.Imbien@eclaro.com
(843) 872-9257
 
Equal Opportunity Employer: Eclaro values diversity and does not discriminate based on Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status.

Application Instructions

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