Job Description

Global Product Development and Supply - Research Associate
Job Number: 21-15498
 
Be part of a company that delivers life-changing healthcare solutions. Eclaro is looking for a Global Product Development and Supply - Research Associate for our client in Seattle, WA. 
 
Eclaro’s client is a leader in the Biopharmaceutical Industry, providing quality, innovative, and affordable medicines that make a difference in the lives of patients all over the world. If you’re up to the challenge, then take a chance at this rewarding opportunity!
 
Position Overview:
  • Client is developing Client cellular immunotherapies based on two distinct and complementary platforms Chimeric Antigen Receptors (CARs) and T Cell Receptors (TCRs) technologies.
  • Goal is to revolutionize medicine by re-engaging the bodys immune system to treat cancer.
  • Client is seeking a Research Associate to join the Potency & Functional Characterization department within Analytical Development.
  • The successful candidate will help facilitate the development of assays that characterize the biological activity (e.g. metabolism, proliferation, effector function, and vector function) of autologous and allogenic cell therapies which are currently undergoing clinical trials, including CAR T cell products.
  • The Research Associate will be able to execute and analyze experiments with some oversight that lead to the development of robust analytical methods.
  • The candidate will have the responsibility for developing highly impactful methods, including QC methods for lot release & stability testing as well as extended characterization methods that support process development and comparability assessments.
  • These methods will be used to further understanding of cell therapies, support development of the manufacturing processes, and/or QC release of the drug product.
  • The Research Associate will have hands-on experience in assay development and will be interested in projects requiring close collaboration with other groups, such as discovery research, product sciences, process development, and QC.
  • The Research Associate will be passionate about developing Client medicines, thrive in an intellectually challenging environment, and enjoy collaborating with a team of likeminded Scientists.
 
Responsibilities:
  • Execute, analyze, and document experiments to develop cell-based potency methods for lentiviral and AAV vectors
  • Develop suitable assay acceptance criteria and establish control ranges
  • Provide updates on a regular basis at the Potency department meeting
  • Work with internal collaborators to design and conduct method qualification experiments
 
Qualifications:
  • Basic Qualifications:
    • B.S. with > 2 years of experience in the field of Immunology, Cell Biology, or Cancer Biology, preferably in an industry setting
    • Experience developing and qualifying cell-based assays, ELISAs, or similar technology platforms (e.g. MSD, Luminex, AlphaLISA, etc.).
    • Experience with cell culture, primary human cells, and cryopreservation.
  • Preferred Qualifications:
    • Proficiency with relative potency methods, Four-Parameter and Five Parameter Logistic Curve Fit models, robustness assessments, establishing system suitability criteria, critical reagent qualification procedures, analyst training, method transfers, and/or method qualification/validation.
    • Experience with Design of Experiment (DoEs) using JMP or equivalent statistical software.
    • Experienced with authoring and revising test methods, protocols, and technical reports.
 
If interested, you may contact:
Chris Imbien
Chris.Imbien@eclaro.com
(843) 872-9257
 
Equal Opportunity Employer: Eclaro values diversity and does not discriminate based on Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status.
 

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